About Alsonex

Built to Tackle Neurodegenerative Diseases

Alsonex is an Australian-based, clinical-stage biopharmaceutical company developing a new drug for some of the most confounding diseases of humankind. It is led by experienced drug developers with a track record of innovation and translation.

Our story

Founded in 2014, Out of University of Queensland Research

Alsonex is focused on the development of new treatments for neurodegenerative disease. Founded in 2014 from research being undertaken at the University of Queensland and elsewhere into the link between neuroinflammation and neurodegenerative disease.

Neurodegenerative disease remains a complex and elusive goal for the pharmaceutical industry, but new research is shedding some light on the problem, and new treatments are emerging. Alsonex is positioned to provide part of the solution to slowing or reversing diseases such as Parkinson's, Alzheimer's, Huntington's and Motor Neuron Diseases.

Our principal commercial objective. Our principal commercial objective is to develop a new drug treatment for people with neurodegenerative diseases, which aligns with our commercial objective to enhance shareholder value through clinical development of ALS-205.

Aerial view of the University of Queensland's St Lucia campus on a bend of the Brisbane River, with the Brisbane skyline beyond
University of Queensland, St Lucia campus
Our Approach

A Focused Path From the Laboratory to the Patient

01

Validated Targets

Alsonex builds on well-understood biology. Its programmes begin with validation of the biochemical target — the complement system and the C5a1 receptor that drives damaging neuroinflammation — establishing a sound scientific basis before a molecule advances toward patients.

02

Proof-of-Concept

A key part of the business model is to advance products through to the proof-of-concept stage in patients. For the longer and more costly clinical studies, development risk is shared with a larger pharmaceutical or biotechnology partner.

03

Pipeline Expansion

The lead molecule, ALS-205, is being expanded into other degenerative diseases of the CNS, benefiting from the preclinical work already undertaken for the first indication. Additional indications include Alzheimer's and Huntington's disease, widening the clinical frontier from a single validated molecule.

Our Leadership Team

Experienced Drug Developers and Proven Operators

David Groth
David Groth
Non-Executive Chairman

David is a co-founder and director of Integra Advisory, with over 20 years of experience advising companies and in senior management positions. He has managed a significant number of initial public offers, secondary capital raisings, mergers and acquisition transactions as part of developing and maintaining long-term relationships with clients. David has also held a number of senior management positions (including CEO), giving him a management and client perspective of capital raisings, M&A transactions, strategic advice and stakeholder/investor relations. Prior to establishing Integra Advisory, David spent 18 years at Wilson HTM, where he held several senior positions, including Chief Executive Officer.

Alan Robertson
Alan Robertson
Chief Executive Officer and Managing Director

Alan was the CEO and MD of Pharmaxis Ltd for 14 years, responsible for raising more than $350 million in the U.S., Europe and Australia. In that role he oversaw the development to Marketing Authorisation of a new inhaled dry powder treatment for cystic fibrosis (Bronchitol) and a bronchial challenge test for hyperactive airway disease (Aridol). He built a drug discovery capability within Pharmaxis and participated in the creation of PXS4728 — now licensed to Boehringer Ingelheim for the treatment of NASH. Previously, he was the CEO of Promics Ltd (now part of Teva) and developed the first C5a receptor antagonist to patients with rheumatoid arthritis. While head of drug discovery at Kinacia, he invented KN-309, a PI3 kinase inhibitor (subsequently licensed to AstraZeneca). He is a former member of the scientific advisory board of Xenome Limited, a former Non-Executive Director of Patrys Limited and is a current Non-Executive Director of Infensa Bioscience Ltd and Chairman of AllVascular Ltd. While in the UK, as a Senior Scientist at Wellcome PLC (now GSK), he invented the anti-migraine drug Zomig.

Steven Boggiano
Steven Boggiano
Non-Executive Director

Steven possesses over twenty years' executive management and investment banking experience across North America (New York), Europe (London) and Asia Pacific (Hong Kong / Sydney). During his career, Steven has advised on a broad range of listed and unlisted mergers, divestments, acquisitions, strategic reviews, restructurings and capital raisings within Healthcare. Previously Steven was Managing Director and Head of Asia for Healthcare at Barclays Investment Bank and the former Chief Strategy Officer and Acting Chief Financial Officer of Estia Health. He is currently the Head of Healthcare and M&A at Ord Minnett.

Trent Woodruff
Trent Woodruff
Scientific Advisor

A/Prof Woodruff is an ARC Future Fellow conducting research into the innate immune system in the brain, with specific research revolving around the Complement System. A focus of his work has been the chronic neurodegenerative diseases amyotrophic lateral sclerosis, Huntington's disease and Parkinson's disease, as well as maintaining an active interest in Alzheimer's disease. In 2010, A/Prof Woodruff started his own group and independent laboratory at the University of Queensland.

Alan Scott
Alan Scott
Non-Executive Director

Alan has experience in corporate reorganisation and M&A. He was the previous Chairman and Managing Director of Progen Industries for 11 years, including listing on the ASX and completing a direct NASDAQ cross listing. More recently, he was the Managing Director of Promics Pty Ltd and executed a trade sale to Cephalon/Teva. Currently, he is the CEO of Biosecurity/Opti Grow.

Paul Field
Paul Field
Strategic Advisor

Paul has over 25 years of business development experience across a range of disease areas, including CNS disorders, and a deep network in the global biopharmaceutical industry. His current roles include business development manager at BioCurate, established in 2017 by Monash University and the University of Melbourne to commercialise drug discoveries in their two institutions. He was previously the life sciences specialist at Austrade, the Australian Government’s investment promotion agency, where he facilitated foreign direct investment into Australian research in infectious diseases, autoimmune diseases, neurodegenerative diseases, cancer and other therapeutic areas. Earlier, Paul was the founder and Executive Chairman of Bio-Link, a privately-owned biotechnology business development company with a range of clients across Australia.

Our Affiliations
For investors & partners

Partner With Us to Bring ALS-205 to Patients

Alsonex advances its programmes to proof-of-concept, then shares later-stage development with the right pharmaceutical partner.

Contact the team